In a match worthy of being a Grand Slam final, tennis greats Rafael Nadal and Novak Djokovic squared off in a blockbuster quarter-final at the 2022 French Open at Roland Garros in Paris on Wednesday. It will be the first match in tennis history with two players with 20 Grand Slam titles; Nadal holds a record of 21, one more than Djokovic and Roger Federer. It will also be the 59th meeting between the two rivals; no tennis rivalry has been played more often. The game won’t start until 2:45 p.m. ET.

For Tuesday, Djokovic is a -250 favorite (risk $250 to win $100) in Caesars Sportsbook’s latest Djokovic vs. Nadal odds, while Nadal is a +190 underdog. The over-under for total games is 36.5. Before you make any picks at Roland Garros 2022, be sure to see the latest tennis predictions from SportsLine’s Sean Calvert.

Calvert is the handicapper who called out Stan Wawrinka in winning the 2014 Australian Open 60-1. At the 2018 Miami Open, he did even better, correctly calling 100-1 long shot John Isner to win the title. And in 2019, Calvert notched a huge score over Dominic Thiem winning Indian Wells 80-1. Anyone who follows their choices is at the top.

Now Calvert has locked down the 2022 French Open men’s quarter-final match with Djokovic against Nadal and has revealed his best bets. Head over to SportsLine to see them.

Best Djokovic vs Nadal Predictions

The tournament seed, Djokovic has been dominant on clay in his last two tournaments. In his last nine matches in Rome and Paris, Djokovic hasn’t even conceded a set. In four matches at Roland Garros, he only once gave up more than three games in a set: in the second round against Alex Molcan, who extended Djokovic until the third set tiebreaker.

Djokovic comes into Tuesday’s game with the advantage on serve, on paper. So far in this tournament, the 35-year-old Serb has hit 31 aces, landed 71% of his first serves and converted 77% of the points behind his first serve. In contrast, Nadal has just seven aces, landed 65% of his first serves and converted 73% of the points behind his first serve.

However, Nadal is the greatest clay-court player of all time. The 35-year-old Spaniard has won a record 13 French Open singles titles, seven more than the most important player of the Open era, Bjorn Borg. In 112 singles matches at Roland Garros, Nadal has lost only three times.

How to make choices between Nadal and Djokovic

Calvert is tipping under 36.5 games overall (+100), but he has two even stronger bets, including a prop that comes back almost 2-1. Be sure to see Calvert’s picks and analysis before you make your picks at Roland Garros 2022 for the men’s quarter-final.

Who wins Nadal against Djokovic in the men’s quarter-final of Roland-Garros 2022? And what more-money bet does Calvert like? Visit SportsLine now to see Sean Calvert’s best bets for Djokovic vs. Nadal, all from the tennis handicapper with a history of making big calls.